Cancer
C3M teams study the molecular and cellular mechanisms involved in cancers such as leukemia, lymphoma, melanoma, prostate, lung and liver cancer. They are also interested in the processes involved in therapeutic resistance and metastasis and in deciphering the tumour microenvironment. Our objectives are to gain a better understanding of these diseases and to identify new therapeutic targets in order to develop new treatments that are more effective and more individual. The research work carried out by our teams places C3M at the forefront of translational research in the field of cancer and has led to the creation of several biotechnology startups.
Infection and inflammation
The C3M teams are interested in the processes of infection and normal or pathological inflammation. They study the cellular and molecular mechanisms that regulate the virulence of microbes and the immune response during infection or in metabolic diseases, skin diseases and cancers. The new therapeutic targets identified allow the development of drugs and therapies that place C3M at the forefront of translational research on infectious and inflammatory diseases.
Metabolic diseases
C3M teams study the mechanisms underlying the development of obesity and cardiometabolic diseases, including insulin resistance, type 2 diabetes, Metabolic Associated Fatty Liver Disease (MAFLD) and cardiovascular diseases. They are interested in the role of adipose tissue dysfunction in insulin resistance, the link between metabolism, immunity and inflammation in the development of cardiometabolic diseases and the progression of hepatic steatosis to Non-Alcoholic SteatoHepatitis (NASH). Our research aims to better understand the mechanisms of the development of these diseases, in order to identify new therapeutic targets and develop innovative therapies. Thanks to close collaboration with the clinical services of Nice University Hospital, the C3M is at the forefront of translational research on metabolic diseases.
