Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression.
Journal of the National Cancer InstituteApr 2017
Description
MITF encodes an oncogenic lineage-specific transcription factor in which a germline mutation ( MITFE318K ) was identified in human patients predisposed to both nevus formation and, among other tumor types, melanoma. The molecular mechanisms underlying the oncogenic activity of MITF E318K remained uncharacterized.